Lisinopril Liver Damage


Lisinopril (Prinivil & Zestril) Linked to Various Severe Adverse Effects


lisinopril_box.jpgLisinopril is a drug of the angiotensin-converting enzyme (ACE) inhibitor class that is primarily used in treatment of hypertension, congestive heart failure, and heart attacks and also in preventing renal and retinal complications of diabetes. It was developed by Merck & Co. and is marketed worldwide as Prinivil or Tensopril and by AstraZeneca as Zestril. In the past few years Lisinopril side effects have been linked to liver damage and liver failure which are life-threatening and often fatal.

Adverse Effects:

  • Liver damage & Acute Liver Failure (ALF)
    • Signs of such liver damage include dark urine, fatigue, jaundice, nausea and stomach/abdominal pain.
  • Hyponatremia
    • Chronic hyponatremia is a metabolic condition in which there is not enough sodium (salt) in the body fluids outside the cells. It can lead to such complications as neurological impairments that affect gait and attention and can lead to falls, osteoporosis, and decreased reaction time.
  • Severe Angioedema & Respiratory Distress
    • Angioedema: a swelling, similar to hives, but the swelling is beneath the skin rather than on the surface which can be life-threatening due to severe associated respiratory symptoms.
  • Other side effects, some or all of which are serious and require immediate medical attention, include:
    • Severe Allergic Reaction (Anaphylaxis): A rare but severe allergic reaction can occur that affects the bowel wall and secondarily causes abdominal pain and requires immediate medical attention.
    • Hyperkalemia: higher-than-normal levels of potassium in the blood
    • Chills, signs of infection
    • Dark urine, decreased urination (oliguria)
    • Hoarseness
    • Itching
    • Yellowing of skin or eyes (jaundice)
    • Abdominal pain, bloating, vomiting
    • Chest pain or tightness, dizziness, lightheadedness, fainting (syncope)
    • Dry cough
    • Fever
    • Joint pain
    • Rash
    • Diarrhea, nausea
    • Drowsiness, headache, tiredness
    • Muscle cramps
    • Fainting/blackouts

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